Syngene, a world-leading manufacturer of image analysis solutions is delighted to introduce PXi, a new high resolution, multi-application image analysis system.

This powerful system is currently the best in its class for scientists that want a compact, one-click method for accurately imaging chemiluminescent and fluorescent blots, as well as 1-D gels (up to 10cm x 12 cm) stained with any type of fluorescent dye.

Generate perfect images of chemiluminescent blots in one click

The innovatively designed compact PXi, with its high resolution 6.3 million pixel camera and large fixed aperture lens can quickly image even the faintest bands. It is easy to fit a range of lighting including IR lighting and filter options inside the PXi system and by using  Syngene’s intuitive GeneSys imaging software, the PXi can be rapidly set up to automatically select the best conditions. Scientists can generate perfect images of chemiluminescent blots, as well as 1-D gels (up to 10cm x 12cm) stained with any fluorescence and IR commercial dyes time after time, with just one-click.

GeneTools, Syngene’s accurate image analysis software, which comes with the PXi saves valuable time by automatically producing results in seconds, including; 1-D lane analysis, molecular weight and quantity calculations.

Laura Sullivan, Syngene’s Divisional Manager stated: “Syngene is well known for its imaging innovation and using the technology from our popular G:BOX, we have really pulled out all the stops by developing a unique high performance imaging system. The system is so compact, yet produces exceptional images of every type of chemi blot, as well as fluorescent blots and gels.”

For Further Information Contact:

Jayne Arthur, Syngene, Beacon House, Nuffield Road, Cambridge, CB4 1TF, UK.

Tel: +44(0) 1223-727123 Fax +44 (0) 1223-727101

Email: jayne.arthur@syngene.com Web site: www.syngene.com

Syngene’s G:BOX imaging system is being used by scientists at a major European research centre to help visualise protein signals which will detect how cells in the human body react to new drugs.

Scientists at the research centre are using a high resolution G:BOX system to accurately analyse fluorescent and chemiluminescent proteins on Western blots. The system is also being used to visualise proteins on 1D and 2D protein gels stained with Coomassie blue and agarose gels of DNA stained with Sybr Safe™ and Ethidium bromide. The information from the gels and blots is being used to determine the effectiveness of new therapeutics, which could potentially speed up drug development.

A researcher in the research centre commented: “We are using DNA-based reporter plasmids to help construct an integrated array of sensors. When a drug excites the sensors a unique protein expression signature pattern is produced and these are being used to compile a reference catalogue of signature patterns. To study this protein expression, we run a large number of 1D and 2D protein gels so we need an easy to use, yet accurate imaging system.”

“Using G:BOX we can easily view our blots and accurately quantify protein expression”

The researcher added: “We reviewed systems from two other suppliers before we installed our G:BOX in 2008 but we were not able to achieve the level of 2D gel imaging and analysis we wanted with either system. In the time we have been using the G:BOX we have found we can easily view our blots and accurately quantify protein expression, without needing a manual and an hour to get up and running and this has helped us advance our project.”

“Any new technology to reduce the time and expense of detecting those effective drugs is so important…”

Laura Sullivan, Syngene’s Divisional Manager, explained: “Thousands of drugs are tested each year but only a fraction are used to treat patients and this is why any new technology to reduce the time and expense of detecting those effective drugs is so important. We are delighted that our imaging system is playing a role in this project because it is proving that for high throughput analysis of 2D gels, a high resolution G:BOX system really does offer exceptional performance.”

For Further Information Contact:

Jayne Arthur, Syngene, Beacon House, Nuffield Road, Cambridge, CB4 1TF, UK.

Tel: +44(0) 1223-727123 Fax +44 (0) 1223-727101

Email: jayne.arthur@syngene.com Web site: www.syngene.com

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Syngene is delighted to introduce the G:BOX F³, a new gel imaging system for rapid, versatile imaging and analysis of DNA, RNA and proteins in gels.

G:BOX F³ has a high-resolution 3.8 million pixel CCD camera with a motor driven lens and built in filter wheel contained in a compact darkroom. This automated system is controlled by Syngene’s intuitive GeneSys imaging software.

High quality gel images are quick and easy to generate

GeneSys software saves time and effort by automatically setting up the optimum lighting and filters from its unique database of imaging conditions for every commercially available DNA, RNA and protein dye. Users can in one screen touch, choose their preferred imaging conditions and the G:BOX F³ will capture automatically a high-quality gel image.

Excellent safety features

Inside the G:BOX F³ system’s safe, light tight cabinet there is overhead Epi white light. Epi UV light, a UV transilluminator and visible light converter options can also be fitted.

For laboratories where safety and UV sample damage are an issue, Syngene offers an UltraBright LED blue light transilluminator, which slides out of the darkroom to aid viewing and band cutting. Additionally, this transilluminator can be fitted with an optional visible light converter screen for viewing protein gels.

Quantative analysis of protein and DNA gels in seconds

The G:BOX F³ system also includes unlimited copies of GeneTools image analysis software to enable each researcher in the laboratory to use their own computer to rapidly generate quantitative analysis of their protein and DNA gels in seconds.

“The best, budget, automated gel imaging technology currently on the market”

Laura Sullivan, Syngene’s Divisional Manager stated: “The G:BOX F³ is a well priced system that is suited to busy labs where researchers are working with a range of different gels. It is ideal for experienced users and novices alike as they only have to know what type of gel they have run and what it is stained with, and the system will select and set up the right imaging conditions for them. Since the technology is so versatile, this makes the G:BOX F³ system the best, budget, automated gel imaging technology currently on the market.”

For Further Information Contact:

Jayne Arthur, Syngene, Beacon House, Nuffield Road, Cambridge, CB4 1TF, UK.

Tel: +44(0) 1223-727123 Fax +44 (0) 1223-727101

Email: jayne.arthur@syngene.com Web site: http://www.syngene.com/g-box/

InGenius gel imaging system, developed by Syngene, is being used by scientists at the the prestigious School of Medicine at the University of Glasgow to determine the types of microorganisms associated with Crohn’s Disease and Coeliac Disease.

Key work that could help determine effective methods to treat and control these diseases

Researchers are using a Syngene InGenius gel doc system to visualise microbial DNA stained with SYBR^® Green on Temporal Temperature Gradient Electrophoresis polyacrylamide gels.

The information obtained is being used to determine which microflora are associated with Crohn’s Disease and Coeliac Disease in children and could help to determine the most effective methods to treat and control these conditions.

Dr Konstantinos Gerasimidis, Lecturer in Clinical Nutrition at the School of Medicine, University of Glasgow commented: “We are looking for microbes in children suffering with digestive diseases and are trying to determine those most prevalent in their colonic samples.

For that we use a variety of molecular microbiology techniques such as Temporal Temperature Gradient Electrophoresis Gels stained with SYBR Green Nucleic Acids Staining. We prefer to use SYBR Green for visualising the DNA, rather than Ethidium bromide because it is significantly more sensitive and less toxic.”

“We upgraded to InGenius because it is more sensitive than other gel doc imagers”

Dr Gerasimidis continued: “We decided to upgrade our gel doc to an InGenius system because we have found it is more sensitive than other imagers we looked at in the same price range. We can easily visualise our DNA so we’re pleased we chose an InGenius.”

Laura Sullivan, Syngene’s Divisional Manager, concluded: “Establishing the potential causes of chronic digestive diseases is critical research and we are excited to hear that the InGenius is playing a part in this. The results researchers at University of Glasgow are obtaining, demonstrate to molecular biologists looking for an inexpensive system to safely and accurately image their DNA, that all they need is an InGenius.”

For Further Information, Contact:

Jayne Arthur, Syngene, Beacon House, Nuffield Road, Cambridge, CB4 1TF, UK.

Tel: +44(0) 1223-727123 Fax +44 (0) 1223-727101

Email: jayne.arthur@syngene.com Web site: www.syngene.com/ingenius/

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Syngene has introduced its new InGenius³ feature-packed gel imaging system.

Designed with a compact darkroom, as well as blue, white and UV lighting options, InGenius³ offers maximum gel imaging versatility at an affordable price.

Easy to optimise quality of each gel image

The InGenius³ features a high-resolution 3 million pixel CCD camera that can be connected to the laboratory’s choice of PC. The system is controlled by Syngene’s intuitive GeneSys imaging software, which guides scientists to the correct combination of filters and lighting, making it easy to set up InGenius³  to produce high quality gel images every time.

Multiple illumination options

The InGenius³ system comes with overhead Epi white light and offers multiple illumination options. These include the new Ultra-Slim LED Blue Light Transilluminator, which is ideal for laboratories where safety and UV sample damage are a major concern.  The transilluminator slides out of the darkroom to aid viewing and cutting gel bands, and there is a White Light Converter screen option for scientists wanting to view protein gels.

The InGenius³ system has manual control functionality, enabling users to easily change lighting conditions, camera aperture, zoom and focus, and quickly switch between filters using a filter drawer. The system also includes GeneTools image analysis software to enable scientists to rapidly analyse their gel images.

“Ideal choice when budget and size are the most important considerations, but high resolution imaging is also a priority”

Laura Sullivan, Syngene’s Divisional Manager stated: “To continue Syngene’s theme of easy imaging, the new InGenius³ is the ideal economical choice when budget and size are the most important considerations, but high resolution imaging is also a priority.”

Laura concluded, “This is why we are pleased to introduce our InGenius³ Gel Documentation system. The system is specifically designed for viewing gels in laboratories where bench space is limited, yet doesn’t compromise on performance, which means capturing great gel images every time has never been easier.”

For Further Information Contact:

Jayne Arthur, Syngene, Beacon House, Nuffield Road, Cambridge, CB4 1TF, UK.

• Tel: +44(0) 1223-727123 Fax +44 (0) 1223-727101
• Email: jayne.arthur@syngene.com
• Web site: www.syngene.com/ingenius/

UGenius gel doc system

Syngene, a world-leading manufacturer of image analysis solutions today introduced its U:Genius³, a complete budget gel imaging system. This compact system with its button driven key pad is simple to set up, making it ideal for busy laboratories that need rapid and accurate gel imaging.

Highly accurate, yet cost-effective

The U:Genius³ comes with a sensitive 3 million pixel CCD camera inside a compact darkroom. The cost-effective system includes overhead Epi white light and is versatile, offering multiple illumination options to allow high-resolution imaging of 1D DNA and protein gels stained with a range of dyes.

Simple, safe, space-efficient

U:Genius³ features a built in processor and simple to use intuitive “button controlled” integral key pad so can be used straight from the box. The system can be fitted with the new Ultra-Slim LED Blue Light Transilluminator in laboratories where safety and UV sample damage are issues.

The transilluminator slides out of the darkroom to aid viewing and band cutting, and there is also a white light converter screen option available for scientists wanting to view protein gels, thus maximising the use of vital laboratory space.

“The most cost-effective gel doc currently available”

Laura Sullivan, Syngene’s Divisional Manager explained: “Many researchers in busy laboratories often just want a quick, accurate image of their gels, so they need an inexpensive press button system which takes seconds to set up.”

Laura added: “We have listened to those requests and the result is the U:Genius³. We’re confident that scientists who try the U:Genius³ will agree the system is ideal where budget and space are limited, but doesn’t compromise on generating superb results with outstanding resolution, making U:Genius³ the most cost-effective gel doc currently available.”  

For Further Information Contact:

Jayne Arthur, Syngene, Beacon House, Nuffield Road, Cambridge, CB4 1TF, UK.

Tel: +44(0) 1223-727123 Fax +44 (0) 1223-727101

Email: jayne.arthur@syngene.com Web site: www.syngene.com/ugenius/

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